2024
Jaschke NP, Breining D, Hofmann M, Pählig S, Baschant U, Oertel R, Traikov S, Grinenko T, Saettini F, Biondi A, Stylianou M, Bringmann H, Zhang C, Yoshida TM, Weidner H, Poller WC, Swirski FK, Göbel A, Hofbauer LC, Rauner M, Scheiermann C, Wang A, Rachner TD. Small-molecule CBP/p300 histone acetyltransferase inhibition mobilizes leukocytes from the bone marrow via the endocrine stress response. Immunity. 2024 Feb 13;57(2):364-378.e9. doi: 10.1016/j.immuni.2024.01.005. Epub 2024 Jan 31. PMID: 38301651.
2023
De Virgiliis F, Mueller F, Palmisano I, Chadwick JS, Luengo-Gutierrez L, Giarrizzo A, Yan Y, Danzi MC, Picon-Muñoz C, Zhou L, Kong G, Serger E, Hutson TH, Maldonado-Lasuncion I, Song Y, Scheiermann C, Brancaccio M, Di Giovanni S. The circadian clock time tunes axonal regeneration. Cell Metab. 2023 Nov 3:S1550-4131(23)00381-9. doi: 10.1016/j.cmet.2023.10.012. Epub ahead of print. PMID: 37951214.
Wang C, Barnoud C, Cenerenti M, Sun M, Caffa I, Kizil B, Bill R, Liu Y, Pick R, Garnier L, Gkountidi OA, Ince LM, Holtkamp S, Fournier N, Michielin O, Speiser DE, Hugues S, Nencioni A, Pittet MJ, Jandus C, Scheiermann C. Dendritic cells direct circadian anti-tumour immune responses. Nature. 2022 Dec 5. doi: 10.1038/s41586-022-05605-0. Online ahead of print.PMID: 36470303.
Ince LM, Barnoud C, Lutes LK, Pick R, Wang C, Sinturel F, Chen CS, de Juan A, Weber J, Holtkamp SJ, Hergenhan SM, Geddes-McAlister J, Ebner S, Fontannaz P, Meyer B, Vono M, Jemelin S, Dibner C, Siegrist CA, Meissner F, Graw F, Scheiermann C. Influence of circadian clocks on adaptive immunity and vaccination responses. Nat Commun. 2023 Jan 30;14(1):476. doi: 10.1038/s41467-023-35979-2. PMID: 36717561; PMCID: PMC9885059.
2022
De Virgiliis F, Oliva VM, Kizil B, Scheiermann C. Control of lymph node activity by direct local innervation. Trends Neurosci. 2022 Sep;45(9):704-712. doi: 10.1016/j.tins.2022.06.006. Epub 2022 Jul 9. PMID: 35820971.
Garnier L, Pick R, Montorfani J, Sun M, Brighouse D, Liaudet N, Kammertoens T, Blankenstein T, Page N, Bernier-Latamani J, Tran NL, Petrova TV, Merkler D, Scheiermann C, Hugues S. IFN-γ-dependent tumor-antigen cross-presentation by lymphatic endothelial cells promotes their killing by T cells and inhibits metastasis. Sci Adv. 2022 Jun 10;8(23):eabl5162. doi: 10.1126/sciadv.abl5162. Epub 2022 Jun 8. PMID: 35675399; PMCID: PMC9176743.
Wang C, Lutes LK, Barnoud C, Scheiermann C. The circadian immune system. Sci Immunol. 2022 Jun 3;7(72):eabm2465. doi: 10.1126/sciimmunol.abm2465. Epub 2022 Jun 3. PMID: 35658012.
2021
Holtkamp SJ, Ince LM, Barnoud C, Schmitt MT, Sinturel F, Pilorz V, Pick R, Jemelin S, Mühlstädt M, Boehncke WH, Weber J, Laubender D, Philippou-Massier J, Chen CS, Holtermann L, Vestweber D, Sperandio M, Schraml BU, Halin C, Dibner C, Oster H, Renkawitz J, Scheiermann C. Circadian clocks guide dendritic cells into skin lympthatics. Nat. Immunol. 2021 Nov;22(11):1375-1381.
Pinho S, Lucas D, Scheiermann C, Hidalgo A. Paul S. Frenette (1965-2021). Nat Cell Biol. 2021 Oct;23(10):1049-1050. doi: 10.1038/s41556-021-00761-3. PMID: 34561616.
Harlé G, Kowalski C, Dubrot J, Brighouse D, Clavel G, Pick R, Bessis N, Niven J, Scheiermann C, Gannagé M, Hugues S. Macroautophagy in lymphatic endothelial cells inhibits T cell-mediated autoimmunity. Journal of Experimental Medicine. 2021 218(6):e20201776.
Bromberger T, Klapproth S, Rohwedder I, Weber J, Pick R, Mittmann L, Min-Weißenhorn SJ, Reichel CA, Scheiermann C, Sperandio M, Moser M. Binding of Rap1 and Riam to Talin1 Fine-Tune β2 Integrin Activity During Leukocyte Trafficking. Front Immunol. 2021 Aug 19;12:702345. doi: 10.3389/fimmu.2021.702345. PMID: 34489950; PMCID: PMC8417109.
Barnoud C, Wang C, Scheiermann C. Timing vaccination against SARS-Cov-2. Cell Res.2021 Nov;31(11):1146-1147.
Lucas D, Scheiermann C, Hidalgo A. In memory of a game-changing haematologist. Nature. 2021 Sep;597(7874):31. doi: 10.1038/d41586-021-02357-1. PMID: 34465905.
Hinterdobler J, Schott S, Jin H, Meesmann A, Steinsiek AL, Zimmermann AS, Wobst J, Müller P, Mauersberger C, Vilne B, Baecklund A, Chen CS, Moggio A, Braster Q, Molitor M, Krane M, Kempf WE, Ladwig KH, Hristov M, Hulsmans M, Hilgendorf I, Weber C, Wenzel P, Scheiermann C, Maegdefessel L, Soehnlein O, Libby P, Nahrendorf M, Schunkert H, Kessler T, Sager HB. Acute mental stress drives vascular inflammation and promotes plaque destabilization in mouse atherosclerosis. Eur Heart J. 2021 Oct 14;42(39):4077-4088. doi: 10.1093/eurheartj/ehab371. PMID: 34279021; PMCID: PMC8516477.
Chen, CS., Weber, J., Holtkamp, SJ., Ince, LM., de Juan, A., Wang, C., Lutes, L., Barnoud, C., Kizil, B., Hergenhan, SM., Salvermoser, J., Lasch, M., Deindl, E., Schraml, B., Baumjohann, D., Scheiermann, C. Loss of direct adrenergic innervation after peripheral nerve injury causes lymph node expansion through IFN-y. Journal of Experimental Medicine. 2021 218(2):e20202377.
Holtkamp, S., Scheiermann, C. Ex vivo whole-mount imaging of leukocyte migration to the bone marrow. Methods in Molecular Biology 2021 2308:139-150.
Gkountidi, A., Garnier, L., Dubtor, J., Angelillo, J., Harlé, G., Brighouse, D., Wrobel, LJ., Pick, R., Scheiermann, C., Swartz, MA., Hugues, S. MHC Class II Antigen Presentation by Lymphatic Wndothelial Cells in Tumors Promotes Intratumoral Regulatory T cell-Suppressive Functions. Cancer Immunology Research. 2021 in press.
Harlé, G., Kowalski, C., Dubrot, J., Brighouse, D., Clavel, G., Pick, R., Bessis, N., Niven, J., Scheiermann, C., Gannagé, M., Hugues, S. Macroautophagy in lymphatic endothelial cells inhibits T cell-mediated autoimmunity. Journal of Experimental Medicine. 2021 218(6):e20201776.
2020
Ikuta, K., Scheiermann, C. Editorial: Circadian control of Immunity. Frontiers in Immunology 2020 11:618843
Chen, C., Barnoud, C., Scheiermann, C. Influence of peripheral neurotransmitters on the immune system. Current Opinion in Physiology. 2020 in press (19:xx-yy).
Bogoslowski, A., Wijeyesinghe, S., Lee, WY., Chen, C., Alanani, S., Jenne, C., Steeber, DA., Scheiermann, C., Butcher, EC., Masopust, D., Kubes, P. Neutrophils Recirculate Through Lymph Nodes to Survey Tissues for Pathogens. Journal of Immunology. 2020 204(9):2552-2561.
Hergenhan, S., Holtkamp, S., Scheiermann, C. Molecular Interactions Between Components of the Circadian Clock and the Immune System. Journal of Molecular Biology. 2020 432(12):3700-3713.
2019
De Juan, A., Ince, L., Pick, R., Molica, F., Zuchtriegel, G., Wang, C., Zhang, D., Druzd, D., Hessenauer, M., Pelli, G., Kolbe, I., Oster, H., Prophete, C., Hergenhan, S., Albrecht, U., Ripperger, J., Montanez, E., Reichel. C., Soehnlein, O., Kwak, B., Frenette, P., Scheiermann, C. Artery-Associated Sympathetic Innervation Drives Rhythmic Vascular Inflammation of Arteries and Veins. Circulation. 2019 13(140):1100–1114.
Pick, R., He, W., Chen, C., Scheiermann, C. Time-Of-Day Dependend Trafficking and Function of Leukocyte Subsets. Trends in Immunology 2019 6:40.
Ince, L., Weber, J., Scheiermann, C. Control of Leukocyte Trafficking by Stress-Associated Hormones. Frontiers in Immunology 2019 9:3143.
2018
He, W., Holtkamp, S., Hergenhan, S., Kraus, K., de Juan, A., Weber, J., Bradfield, P., Grenier, J., Pelletier, J., Druzd, D., Chen, C., Ince, L., Bierschenk, S., Pick, R., Sperandio, M., Scheiermann, C. Circadian Expression of Migratory Factors
Establishes Lineage-Specific Signatures that Guide the Homing of Leukocyte Subsets to Tissues. Immunity. 2018 49: 1–16.
Moretti FA., Klapproth S., Ruppert R., Margraf A., Weber J., Pick R., Scheiermann C., Sperandio M., Fässler R., Moser M. Differential requirement of kindlin-3 for T-cell progenitor homing to the non-vascularized and vascularized thymus. eLIFE. 2018 7:e35816.
Scheiermann, C., Gibbs, J., Ince, L., & Loudon, A. Clocking in to immunity. Nature Reviews Immunology. 2018 18:423–437. Cover
Winter, C., Silvestre-Roig, C., Ortega-Gomez, A., Lemnitzer, P., Poelman, H., Schumski, A., Winter, J., Drechsler, M., de Jong, R., Immler, R., Sperandio, M., Hristob, M., Zeller, T., Nicolaes, G., Weber, C., Viola, J., Hidalgo, A., Scheiermann, C., Soehnlein, O., Chrono-pharmacologial Targeting of the CCL2-CCR2 Axis Ameliorates Atherosclerosis. Cell Metabolism. 2018 28:175–182.
Stremmel, C., Schuchert, R., Wagner, F., Thaler, R., Weinberger, T., Pick, R., Mass, E., Ishikawa-Ankerhold, H., Margraf, A., Hutter, S., Vagnozzi, R., klapproth, S., Frampton, J., Yona, S., Scheiermann, C., Molkentin, D., Jeshke, U., Moser, M., Sperandio, M., Massberg, S., Geissmann, F., Schulz, C. Yolk sac macrophage progenitors traffic to the embryo during defined stages of development. Nature Communications. 2018 9(75).
2017
Druzd, D., Matveeva, O., Ince, L., Harrison, U., He, W., Schmal, C., Herzel, H., Tsang, A., Kawakami, N., Leliavski, A., Uhl, U., Yao, L., Sander, L., Chen, C., Kraus, K., de Juan, A., Hergenhan, S., Ehlers, M., Koletzko, B., Haas, R., Solbach, W., Oster, H. and Scheiermann, C. Lymphocyte circadian clocks control lymph node trafficking and adaptive immune responses. Immunity. 2017 46:120-132. Cover & Best of Immunity 2017 (http://info.cell.com/best-of-immunity-2017)
2016
Campa, C.C., Germena, G., Ciraolo, E., Copperi, F., Sapienza, A., Franco, I., Ghigo, A., Camporeale, A., Di Savino, A., Martini, M., Perino, A., Megens, R.T., Kurz, A.R., Scheiermann, C., Sperandio, M., Gamba, A., and Hirsch, E. Rac signal adaptation controls neutrophil mobilization from the bone marrow. Sci Signal. 2016 9:ra124.
Ortega-Gomez, A., Salvermoser, M., Rossaint, J., Pick, R., Brauner, J., Lemnitzer, P., Tilgner, J., de Jong, R.J., Megens, R.T., Jamasbi, J., Döring, Y., Pham, C.T., Scheiermann, C., Siess, W., Drechsler, M., Weber, C., Grommes, J., Zarbock, A., Walzog, B., and Soehnlein, O.. Cathepsin G Controls Arterial But Not Venular Myeloid Cell Recruitment. Circulation. 2016 134:1176-1188.
Schloss, M.J., Horckmans, M., Nitz, K., Duchene, J., Drechsler, M., Bidzhekov, K., Scheiermann, C., Weber, C., Soehnlein, O., and Steffens, S. The time-of-day of myocardial infarction onset affects healing through oscillations in cardiac neutrophil recruitment. EMBO Mol Med. 2016 8:937-48.
2015
Alard, J.E., Ortega-Gomez, A., Wichapong, K., Bongiovanni, D., Horckmans, M., Megens, R.T., Leoni, G., Ferraro, B., Rossaint, J., Paulin, N., Ng, J., Ippel, H., Suylen, D., Hinkel, R., Blanchet, X., Gaillard, F., D’Amico, M., von Hundelshausen, P., Zarbock, A., Scheiermann, C., Hackeng, T.M., Steffens, S., Kupatt, C., Nicolaes, G.A., Weber, C. und Soehnlein, O. Recruitment of classical monocytes can be inhibited by disturbing heteromers of neutrophil HNP1 and platelet CCL5. Sci. Trans. Med. 2015 7:317ra196.
Zhang, D., Chen, G., Manwani, D., Mortha, A., Xu, C., Faith, J. J., Burk, R. D., Kunisaki, Y., Jang, J. E., Scheiermann, C., Merad, M., and Frenette, P. S. Neutrophil ageing is regulated by the microbiome. Nature. 2015 525:528-32.
Scheiermann, C., Frenette, P. S. and Hidalgo, A. Regulation of leukocyte homeostasis in the circulation. Cardiovasc. Res. 2015 107:340-51.
2014
Bruns, I., Lucas, D., Pinho, S., Ahmed, J., Lambert, M. P., Kunisaki, K., Scheiermann, C., Schiff, L., Poncz, M., Bergman, A., and Frenette, P. S. Megakaryocytes regulate haematopoietic stem cell quiescence via Cxcl4 secretion. Nat. Med. 2014 20:1315-20.
Druzd, D., de Juan, A., and Scheiermann, C. Circadian rhythms in leukocyte trafficking. Semin. Immunopathol. 2014 36:149-62.
2013
Kunisaki, Y., Bruns, I., Scheiermann, C., Ahmed, J., Pinho, S., Zhang, D., Mizoguchi, T., Wei, Q., Lucas, D., Ito, K., Mar, J. C., Bergman, A., and Frenette, P. S. Arteriolar niches maintain haematopoietic stem cell quiescence. Nature. 2013 502:637-43
Druzd, D. and Scheiermann, C. Some monocytes got rhythm. Science. 2013 341:1462-4.
Lucas, D., Scheiermann, C., Chow, A., Kunisaki, Y., Bruns, I., Barrick, C., Tessarollo, L., and Frenette, P. S. Chemotherapy-induced bone marrow nerve injury impairs hematopoietic regeneration. Nat. Med. 2013 19:695-703
Scheiermann, C., Kunisaki Y., and Frenette, P. S. Circadian control of the immune system. Nat. Rev. Immunol. 2013 13:190-8.
Frenette, P. S., Pinho, S., Lucas, D., and Scheiermann, C. Mesenchymal Stem Cell: Keystone of the Hematopoietic Stem Cell Niche and a Stepping-Stone for Regenerative Medicine. Annu. Rev. Immunol. 2013 31:285-316.
2012
Scheiermann, C., Kunisaki, Y., Lucas, D., Chow, A., Jang, J. E., Zhang, D., Hashimoto, D., Merad, M., and Frenette, P. S. Adrenergic nerves govern circadian leukocyte recruitment to tissues. Immunity. 2012 37:290-301.
Almeida, C. B., Scheiermann, C., Jang, J. E., Prophete, C., Costa, F. F., Conran, N., and Frenette, P. S. Hydroxyurea and a cGMP-amplifying agent have immediate benefits on acute vaso-occlusive events in sickle cell disease mice. Blood. 2012 120:2879-88.
2011
Chow, A., Lucas, D., Hidalgo, A., Méndez-Ferrer, S., Hashimoto, D., Scheiermann, C., Battista, M., Leboeuf, M., Prophete, C., van Rooijen, N., Tanako, M., Merad, M., and Frenette, P. S. Bone marrow CD169+ macrophages promote the retention of hematopoietic stem and progenitor cells in the mesenchymal stem cell niche. J. Exp. Med. 2011 208:261-71.
2010
Scheiermann, C., Kunisaki, Y., Jang, J., and Frenette, P. S. Neutrophil microdomains: linking heterocellular interactions with vascular injury. Curr. Opin. Hematol. 2010 17:25-30.
2005 – 2009
Scheiermann, C., Colom, B., Meda, P., Patel, N. S., Voisin, M. B., Marrelli, A., Woodfin, A., Pitzalis, C., Thiemermann, C., Aurrand-Lions, M., Imhof, B. A., and Nourshargh, S. Junctional adhesion molecule-C mediates leukocyte infiltration in response to ischemia reperfusion injury. Arterioscler. Thromb. Vasc. Biol. 2009 29:1509-15.
Scheiermann, C., Meda, P., Aurrand-Lions, M., Madani, R., Yiangou, Y., Coffey, P., Salt, T. E, Ducrest-Gay, D., Caille, D., Howell, O., Reynolds, R., Lobrinus, A., Yu, A. S., Adams, R. H., Anand, P., Imhof, B. A., and Nourshargh, S. Expression and function of junctional adhesion molecule-C in myelinated peripheral nerves. Science 2007 318:1472-1475.
Bradfield, P. F., Scheiermann, C., Nourshargh, S., Ody, C., Luscinskas, F. W., Rainger, G. E., Nash, G. B., Miljkovic-Licina, M., Aurrand-Lions, M., and Imhof, B. A. JAM-C regulates unidirectional monocyte transendothelial migration in inflammation. Blood 2007 110:2545-2555.
Woodfin, A., Reichel, C. A., Khandoga, A., Corada, M., Voisin, M. B., Scheiermann, C., Haskard, D. O., Dejana, E., Krombach, F., and Nourshargh, S. JAM-A mediates neutrophil transmigration in a stimulus-specific manner in vivo: evidence for sequential roles for JAM-A and PECAM-1 in neutrophil transmigration. Blood 2007 110:1848-56.
Howell, O. W., Palser, A., Polito, A., Melrose, S., Zonta, B., Scheiermann, C., Vora, A. J., Brophy, P. J., and Reynolds, R. Disruption of neurofascin localization reveals early changes preceding demyelination and remyelination in multiple sclerosis. Brain 2006 129:3173-85.
Wang, S., Voisin, M. B., Larbi, K. Y., Dangerfield, J., Scheiermann, C., Tran, M., Maxwell, P. H., Sorokin, L., and Nourshargh, S. Venular basement membranes contain specific matrix protein low expression regions that act as exit points for emigrating neutrophils. J. Exp. Med. 2006 203:1519-32.
Huang, M. T., Larbi, K. Y., Scheiermann, C., Woodfin, A., Gerwin, N., Haskard, D. O., and Nourshargh, S. ICAM-2 mediates neutrophil transmigration in vivo: evidence for stimulus specificity and a role in PECAM-1-independent transmigration. Blood 2006 107:4721-4727.
Nencioni, A., Hua, F., Dillon, C. P., Yokoo, R., Scheiermann, C., Cardone, M. H., Barbieri, E., Rocco, I., Garuti, A., Wesselborg, S., Belka, C., Brossart, P., Patrone, F., and Ballestrero, A. Evidence for a protective role of Mcl-1 in proteasome inhibitor-induced apoptosis. Blood 2005 105:3255-62.